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The student will functionally phenotype highly purified hematopoietic stem cells from a wide range of mouse strains that suffer from accelerated ageing and will measure the telomere length in cells from littermate mice derived from crosses of heterozygous animals with various genetic defects implicated in accelerated ageing using flowcytometry and fluorescence in situ hybridization (flow FISH). Detailed gene expression profiles of highly purified stem cell subsets will be obtained and compare...
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