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Gast
The student will dissect the mitochondrial unfolded protein response (UPRmt) signaling in mouse models known or expected to develop premature ageing phenotypes due to progressive mitochondrial dysfunction.DescriptionWe recently showed that increased mtDNA mutations primarily affect protein-coding genes leading to increased turnover of OXPHOS subunits and therefore loss of respiratory chain complexes and premature ageing. He/she will dissect the role of UPRmt, a major stress-signaling pathway ...
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