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Gast
The student will unravel signaling pathways involved in ROS generation in senescence and determine its impact on hematopoietic stem cell function in vivo. A siRNA screen will be performed and ROS generation will be measured after induction of senescence by gamma-irradiation in human fibroblasts. He/she will study the impact of the ROS regulatory genes on stem cell function in vivo, using late generation telomerase knock-out mice (mTERC-/-). To determine the effect of the newly found genes on ...
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