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Gast
Postdoctoral Research Associate
Summary
The laboratory of Dr. Taosheng Chen studies the roles of nuclear receptors PXR and CAR and the CYP3A subfamily of drug–metabolizing enzymes in regulating drug-induced liver toxicity, tumorigenesis, and cancer drug resistance. We develop novel chemical probes/therapeutic leads by using a multidisciplinary approach (biology, chemistry and structural biology), and use them to interrogate the function of PXR, CAR and CYP3A in order to overcome drug tox…
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Summary
The laboratory of Dr. Taosheng Chen studies the roles of nuclear receptors PXR and CAR and the CYP3A subfamily of drug–metabolizing enzymes in regulating drug-induced liver toxicity, tumorigenesis, and cancer drug resistance. We develop novel chemical probes/therapeutic leads by using a multidisciplinary approach (biology, chemistry and structural biology), and use them to interrogate the function of PXR, CAR and CYP3A in order to overcome drug tox…
Weiterlesen...